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Cognitive Function in Children and Subsequent Type 2 Diabetes

¹ Neuroscience, Uppsala University, Uppsala, Sweden
² Public Health, Örebro University, Örebro, Sweden
³ Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
⁴ Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm
⁵ Clinical Research Centre, Örebro University Hospital, Örebro, Sweden
⁶ Primary Care and Social Medicine, Imperial College, London, U.K

Address correspondence and reprint requests to Dr. Gunilla Maria Olsson, Uppsala University, Neuroscience/Pharmacology, BMC, Box 593, SE-751 24 Uppsala, Sweden. E-mail: gunilla.olsson{at}neuro.uu.se

OBJECTIVE—To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood.

RESEARCH DESIGN AND METHODS—Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years.

RESULTS—Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51–0.87) for general ability and 0.58 (0.44–0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially.

CONCLUSIONS—Impaired cognitive function may precede clinical onset of type 2 diabetes.

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				W. Osika and S. M Montgomery Physical control and coordination in childhood and adult obesity: longitudinal birth cohort study BMJ, August 12, 2008; 337(aug12_3): a699 - a699. [Abstract] [Full Text] [PDF]

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