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Published online January 9, 2008
Diabetes Care 31:637-642, 2008
DOI: 10.2337/dc07-1744
© 2008 by the American Diabetes Association
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Clinical Care/Education/Nutrition/Psychosocial Research
Original Research

Outcome of Diabetic Foot Osteomyelitis Treated Nonsurgically

A retrospective cohort study

Eric Senneville, MD1, Audrey Lombart, MD1, Eric Beltrand, MD2, Michel Valette, MD1, Laurence Legout, MD1, Marie Cazaubiel, MD1, Yazdan Yazdanpanah, MD, PHD1 and Pierre Fontaine, MD, PHD3

1 Diabetic Foot Clinic, Dron Hospital, Tourcoing, France
2 Department of Orthopedic Surgery, Dron Hospital, Tourcoing, France
3 Department of Diabetology, Centre Hospitalier Régional Universitaire of Lille, Lille, France

Address correspondence and reprint requests to Eric Senneville, Infectious Diseases Department, Dron Hospital, 135 rue du Pr Coty 59200 Tourcoing, France. E-mail: esenneville{at}ch-tourcoing.fr

OBJECTIVE—The purpose of this article was to identify criteria predictive of remission in nonsurgical treatment of diabetic foot osteomyelitis.

RESEARCH DESIGN AND METHODS—Diabetic patients who were initially treated without orthopedic surgery for osteomyelitis of the toe or metatarsal head of a nonischemic foot between June 2002 and June 2003 in nine French diabetic foot centers were identified, and their medical records were reviewed. Remission was defined as the absence of any sign of infection at the initial or contiguous site assessed at least 1 year after the end of treatment. A total of 24 demographic, clinical, and therapeutic variables including bone versus swab culture–based antibiotic therapy were analyzed.

RESULTS—Fifty consecutive patients aged 62.2 ± 11.1 years (mean ± SD) with diabetes duration of 16 ± 10.9 years were included. The mean duration of antibiotic treatment was 11.5 ± 4.21 weeks. Bone biopsy was routinely available in four of the nine centers. Overall patient management was similar in the different centers except for the use of rifampin, which was recorded more frequently in patients from centers in which a bone biopsy was available. At the end of a 12.8-month posttreatment mean follow-up, 32 patients (64%) were in remission. Bone culture–based antibiotic therapy was the only variable associated with remission, as determined by both univariate (18 of 32 [56.3%] vs. 4 of 18 [22.2%], P = 0.02) and multivariate analyses (odds ratio 4.78 [95% CI 1.0–22.7], P = 0.04).

CONCLUSIONS—Bone culture–based antibiotic therapy is a factor predictive of success in diabetic patients treated nonsurgically for osteomyelitis of the foot.

Abbreviations: MRSA, methicillin-resistant Staphylococcus aureus.


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