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Published online January 9, 2008
Diabetes Care 31:726-727, 2008
DOI: 10.2337/dc07-1392
© 2008 by the American Diabetes Association
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Epidemiology/Health Services Research
Original Research

Tracking and Prediction of Arterial Blood Pressure From Childhood to Young Adulthood in 868 Patients With Type 1 Diabetes

A multicenter longitudinal survey in Germany and Austria

Ina Knerr, MD, PHD1, Axel Dost, MD, PHD2, Rudolf Lepler, MD3, Klemens Raile, MD4, Edith Schober, MD, PHD5, Wolfgang Rascher, MD, PHD1, Reinhard W. Holl, MD, PHD6 On behalf of the Diabetes Data Acquisition System for Prospective Surveillance (DPV) Scientific Initiative Germany and Austria

1 Children's and Adolescents’ Hospital, University of Erlangen-Nuremberg, Erlangen, Germany
2 University Children's Hospital, Jena, Germany
3 Children's Hospital Wilhelmstift, Hamburg, Germany
4 University Children's Hospital, Berlin, Germany
5 University Children's Hospital, Vienna, Austria
6 Division of Applied Information Technology, University of Ulm, Ulm, Germany

Address correspondence and reprint requests to Ina Knerr, MD, PhD, Children's and Adolescents’ Hospital, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany. E-mail: ina.knerr{at}uk-erlangen.de

OBJECTIVE—Arterial blood pressure was followed in 868 patients with type 1 diabetes aged 6.0–19.9 years in 95 centers in Germany and Austria.

RESEARCH DESIGN AND METHODS—European blood pressure reference data for 28,043 children and adolescents were used with respect to age and sex. Data were stratified into three groups: prepubertal, pubertal, and postpubertal.

RESULTS—Up to 4% of the participants in the younger age-groups and 13.9% of the postpubertal patients exhibited blood pressure values >97th centile. Blood pressure levels correlated with A1C level and BMI Z score. Tracking of blood pressure revealed that children with elevated blood pressure had higher blood pressure in adolescence and young adulthood.

CONCLUSIONS—Patients with higher blood pressure in childhood showed elevated blood pressure later in life. We need to focus on the diagnosis of hypertension in children with type 1 diabetes and to study the efficacy of early intervention.

Abbreviations: CVD, cardiovascular disease • DBP, diastolic blood pressure • SBP, systolic blood pressure


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Copyright © 2008 by the American Diabetes Association.