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Published online January 9, 2008
Diabetes Care 31:761-763, 2008
DOI: 10.2337/dc07-1622
© 2008 by the American Diabetes Association
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Pathophysiology/Complications
Original Research

Retinal Arteriolar Caliber Predicts Incident Retinopathy

The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study

Sophie Louise Rogers, MEPI1, Gabriella Tikellis, PHD1, Ning Cheung, MBBS1, Robyn Tapp, PHD1, Jonathan Shaw, MBBS, PHD2, Paul Z. Zimmet, MBBS, PHD2, Paul Mitchell, MBBS, PHD3, Jie Jin Wang, MMED, PHD1,3 and Tien Yin Wong, MBBS, PHD1,2

1 Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
2 International Diabetes Institute, Caulfield, Australia
3 Centre for Vision Research, University of Sydney, Sydney, Australia

Address correspondence and reprint requests to Tien Yin Wong, MBBS, PhD, Centre for Eye Research, University of Melbourne, 32 Gisborne St., Victoria 3002, Australia. E-mail: twong{at}unimelb.edu.au

Changes in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57–14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy.


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