Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online January 17, 2008
Diabetes Care 31:798-801, 2008
DOI: 10.2337/dc07-1781
© 2008 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc07-1781v1
31/4/798    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Martin, M.
Right arrow Articles by Reaven, P. D.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martin, M.
Right arrow Articles by Reaven, P. D.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Cardiovascular and Metabolic Risk
Original Research

Ethnic Differences in the Relationship Between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women

Marlene Martin, BA1, Latha P. Palaniappan, MD, MS2, Andrea C. Kwan, BA3, Gerald M. Reaven, MD4 and Peter D. Reaven, MD5

1 Stanford University School of Medicine, Stanford, California
2 Department of Health Care and Policy Research, Palo Alto Medical Foundation Research Institute, Palo Alto, California
3 University of California, San Diego, California
4 Division of Cardiovascular Medicine, Falk CVRC, Stanford University, Stanford, California
5 Department of Medicine, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona

Address correspondence and reprint requests to Gerald M. Reaven, MD, Stanford University, Falk CVRC, CV 287, Stanford, California 94305. E-mail: greaven{at}cvmed.stanford.edu

OBJECTIVE—To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance.

RESEARCH DESIGN AND METHODS—Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared.

RESULTS—Mean ± SD total (2,965 ± 1,278 vs. 4,235 ± 160 ng/ml) and HMW (1,001 ± 352 vs. 1,591 ± 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 ± 1,040 vs. 5,133 ± 1,086 ng/ml) and HMW (987 ± 479 vs. 1,935 ± 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS.

CONCLUSIONS—Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.

Abbreviations: HMW, high molecular weight • SSPG, steady-state plasma glucose


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2008 by the American Diabetes Association.