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Published online January 9, 2008
Diabetes Care 31:805-807, 2008
DOI: 10.2337/dc07-1117
© 2008 by the American Diabetes Association
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Cardiovascular and Metabolic Risk
Original Research

Effect of Lifestyle Intervention on the Occurrence of Metabolic Syndrome and its Components in the Finnish Diabetes Prevention Study

Pirjo Ilanne-Parikka, MD1,2, Johan G. Eriksson, MD, PHD3,4, Jaana Lindström, PHD3, Markku Peltonen, PHD3, Sirkka Aunola, PHD5, Helena Hämäläinen, MD, PHD6, Sirkka Keinänen-Kiukaanniemi, MD, PHD7,8,9, Mauri Laakso, MD7,8,10, Timo T. Valle, MD3, Jorma Lahtela, MD, PHD11, Matti Uusitupa, MD, PHD12, Jaakko Tuomilehto, MD, PHD3,4 on behalf of the Finnish Diabetes Prevention Study Group

1 Diabetes Center, Finnish Diabetes Association, Tampere, Finland
2 Department of Research Administration, Pirkanmaa Hospital District, Tampere, Finland
3 Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
4 Department of Public Health, University of Helsinki, Helsinki, Finland
5 Department of Health and Functional Capacity, Laboratory for Population Research, National Public Health Institute, Turku, Finland
6 Research Department, Social Insurance Institution, Turku, Finland
7 Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
8 Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
9 Oulu Health Centre, Oulu, Finland
10 Unit of General Practice, Oulu University Hospital, Oulu, Finland
11 Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
12 Department of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland

Address correspondence and reprint requests to Pirjo Ilanne-Parikka, Matinkatu 6, FIN 33900 Tampere, Finland. E-mail: pirjo.ilanneparikka{at}diabetes.fi

OBJECTIVE—The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components.

RESEARCH DESIGN AND METHODS—A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome.

RESULTS—At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40–0.95]) and in the prevalence of abdominal obesity (0.48 [0.28–0.81]).

CONCLUSIONS—The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.

Abbreviations: DPS, Finnish Diabetes Prevention Study • IGT, impaired glucose tolerance


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