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Published online February 14, 2008
Diabetes Care 31:930-931, 2008
DOI: 10.2337/dc07-1962
© 2008 by the American Diabetes Association
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Epidemiology/Health Services Research
Original Research

Serum Prostate-Specific Antigen Levels in Men With Type 2 Diabetes

Michiaki Fukui, MD1, Muhei Tanaka, MD1, Mayuko Kadono, MD1, Saeko Imai, PHD2, Goji Hasegawa, MD1, Toshikazu Yoshikawa, MD1 and Naoto Nakamura, MD1

1 Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
2 Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan

Corresponding author: Michiaki Fukui, MD, Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. E-mail: sayarinapm{at}hotmail.com

OBJECTIVE—The aims of this study were to examine if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men and to investigate what factors may be associated with serum PSA levels in men with type 2 diabetes.

RESEARCH DESIGN AND METHODS—We compared the serum PSA levels in 224 diabetic men with those in 1,293 healthy men and investigated the relationships between serum PSA levels and various variables.

RESULTS—Except for men aged 40–49 years, serum PSA levels were lower in diabetic men than in healthy men. Multiple regression analysis demonstrated that age, BMI, and presence of diabetes were independent determinants of serum PSA level.

CONCLUSIONS—Serum PSA levels were lower in diabetic men compared with those in healthy men, which is in line with previous reports that patients with type 2 diabetes are at a decreased risk of prostate cancer.

Abbreviations: PSA, prostate-specific antigen


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