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Published online February 5, 2008
Diabetes Care 31:968-970, 2008
DOI: 10.2337/dc07-1536
© 2008 by the American Diabetes Association
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Pathophysiology/Complications
Original Research

Relation of Left Ventricular Function, Mass, and Volume to NT-proBNP in Type 1 Diabetic Patients

Anne Sofie Astrup, MD1, Won Yong Kim, MD2,3, Lise Tarnow, MD1, René M. Botnar, PHD4, Cheryl Simonsen, RT3, Lau Brix, MSC3, Lotte Pietraszek1, Peter Riis Hansen, MD5, Warren J. Manning, MD6 and Hans-Henrik Parving, MD7

1 Steno Diabetes Center, Gentofte, Denmark
2 Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
3 MR-Center, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
4 Department of Nuclear Medicine, Technical University Munich, Munich, Germany
5 Gentofte Hospital, Gentofte, Denmark
6 Department of Medicine, Cardiovascular Division, and the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
7 Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark

Corresponding author: Anne Sofie Astrup, Steno Diabetes Center, Niels Steensensvej 2, 2820, Denmark. E-mail: ansa{at}steno.dk

OBJECTIVES—To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH2-terminal pro-brain natriuretic peptide (NT-proBNP).

RESEARCH DESIGN AND METHODS—In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.

RESULTS—All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.

CONCLUSIONS—Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

Abbreviations: CMR, cardiovascular magnetic resonance imaging • LVM, left ventricular mass • LVF, left ventricular function • NT-proBNP, NH2-terminal pro-brain natriuretic peptide


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