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Published online March 13, 2008
Diabetes Care 31:1123-1125, 2008
DOI: 10.2337/dc07-2195
© 2008 by the American Diabetes Association
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Clinical Care/Education/Nutrition/Psychosocial Research
Original Research

Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

Scott M. Nelson, PHD, MRCOG, Dilys J. Freeman, PHD, Naveed Sattar, PHD, FRCP and Robert S. Lindsay, PHD, FRCP

From the Faculty of Medicine, University of Glasgow, Glasgow, U.K

Corresponding author: Dr. Scott Nelson, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, U.K. G31 2ER. E-mail: s.nelson{at}clinmed.gla.ac.uk

OBJECTIVE—To assess the association of fetal hormones with placental growth and fetal weight–to–placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.

RESEARCH DESIGN AND METHODS—We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.

RESULTS—Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.

CONCLUSIONS—Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.

Abbreviations: CRP, C-reactive protein • CTV, contribution to variance • FPI, fetal weight–to–placental weight ratio index • IGFBP-3, IGF-binding protein-3 • OT1D, offspring of mothers with type 1 diabetes


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Copyright © 2008 by the American Diabetes Association.