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Published online March 10, 2008
Diabetes Care 31:1254-1256, 2008
DOI: 10.2337/dc07-2001
© 2008 by the American Diabetes Association
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Cardiovascular and Metabolic Risk
Original Research

Markedly Blunted Metabolic Effects of Fructose in Healthy Young Female Subjects Compared With Male Subjects

Caroline Couchepin, MD, Kim-Anne Lê, MSC, Murielle Bortolotti, MSC, Joana Amarante da Encarnaçao, BSC, Jean-Baptiste Oboni, BSC, Christel Tran, MD, Philippe Schneiter, PHD and Luc Tappy, MD

From the Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland

Corresponding author: Luc Tappy, MD, Department of Physiology, 7 Rue du Bugnon, CH-1005 Lausanne, Switzerland. E-mail: luc.tappy{at}unil.ch

OBJECTIVE—To compare the metabolic effects of fructose in healthy male and female subjects.

RESEARCH DESIGN AND METHODS—Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding.

RESULTS—Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects.

CONCLUSIONS—Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.


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