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Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients

¹ Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Bern, Switzerland
² Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
³ Department of Internal Medicine, Cantonal Hospital, Olten, Switzerland
⁴ Institute of Clinical Chemistry, Kantonsspital, St. Gallen, Switzerland
⁵ Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Basel, Switzerland

Corresponding author: Christoph Stettler, christoph.stettler{at}insel.ch

OBJECTIVE—To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.

RESEARCH DESIGN AND METHODS—In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).

RESULTS—The correlation coefficients for postprandial glucose values were –0.34 (P < 0.05) for 3 days, –0.38 (P < 0.001) for 1 week, and –0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.

CONCLUSIONS—1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.

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				R. K. Schindhelm, M. Diamant, H. J. Bilo, and R. J. Slingerland Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients: Response to Stettler et al. Diabetes Care, November 1, 2008; 31(11): e89 - e89. [Full Text] [PDF]

				C. Stettler, M. Stahl, S. Allemann, P. Diem, K. Schmidlin, M. Zwahlen, W. Riesen, U. Keller, and E. Christ Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients: Response to Schindhelm et al. Diabetes Care, November 1, 2008; 31(11): e90 - e90. [Full Text] [PDF]