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Published online May 5, 2008
Diabetes Care 31:1582-1584, 2008
DOI: 10.2337/dc08-0025
© 2008 by the American Diabetes Association
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Epidemiology/Health Services Research
Original Research

Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study

Caroline S. Fox, MD, MPH1,2,3, Michael J. Pencina, PHD1,4, Peter W.F. Wilson, MD5, Nina P. Paynter, PHD1,4, Ramachandran S. Vasan, MD1,6 and Ralph B. D’Agostino, Sr, PHD1,4

1 National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
2 National Heart, Lung, and Blood Institute, Bethesda, Maryland
3 Division of Endocrinology, Metabolism, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
4 Boston University Department of Mathematics, Boston, Massachusetts
5 Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
6 Boston University School of Medicine, Boston, Massachusetts

Corresponding author: Caroline S. Fox, foxca{at}nhlbi.nih.gov

OBJECTIVE—We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes.

RESEARCH DESIGN AND METHODS—Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years.

RESULTS—Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men.

CONCLUSIONS—The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.


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