Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online June 16, 2008
Diabetes Care 31:1808-1812, 2008
DOI: 10.2337/dc08-0479
© 2008 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc08-0479v1
31/9/1808    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Becker, C.
Right arrow Articles by Meier, C. R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Becker, C.
Right arrow Articles by Meier, C. R.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Epidemiology/Health Services Research
Original Research

Diabetes in Patients With Idiopathic Parkinson's Disease

Claudia Becker, PHD1, Gunnar P. Brobert, PHD2, Saga Johansson, MD, PHD3,4, Susan S. Jick, DSC5 and Christoph R. Meier, PHD1,5

1 Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
2 AstraZeneca Research and Development, Södertälje, Sweden
3 AstraZeneca Research and Development, Mölndal, Sweden
4 Institute of Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
5 Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachusetts

Corresponding author: Christoph R. Meier, meierch{at}uhbs.ch

OBJECTIVE—Previous observational studies reported inconsistent results on the association between diabetes and Parkinson's disease, and data on the risk of developing incident diabetes in relation to Parkinson's disease are scarce. We aimed at comparing the diabetes prevalence between patients with or without Parkinson's disease and at exploring the risk of developing incident diabetes associated with Parkinson's disease.

RESEARCH DESIGN AND METHODS—We used the U.K.-based General Practice Research Database (GPRD) to 1) compare the diabetes prevalence between Parkinson's disease cases and a matched comparison group free of Parkinson's disease between 1994 and 2005 and to 2) conduct a follow-up study with a nested case-control analysis to quantify the risk of developing new-onset diabetes in association with Parkinson's disease.

RESULTS—The diabetes prevalence was similar in patients with and without Parkinson's disease (adjusted odds ratio [OR] 0.95 [95% CI 0.80–1.14]). In the cohort analysis (incidence rate ratio [IRR] 0.55 [95% CI 0.38–0.81]) and in the nested case-control analysis (adjusted OR 0.53 [95% CI 0.33–0.87]), the risk of developing diabetes was lower in patients with Parkinson's disease than in subjects without. The adjusted OR for patients with Parkinson's disease who were current levodopa users of five or more prescriptions was 0.22 (0.10–0.48) and was 1.11 (0.50–2.45) for Parkinson's disease patients not using levodopa.

CONCLUSIONS—In this observational study, diabetes prevalence was closely similar between patients with Parkinson's disease and subjects without. The risk of developing incident diabetes was lower for patients with Parkinson's disease than for patients without, a finding that was limited to Parkinson's disease patients who were using levodopa.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2008 by the American Diabetes Association.