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Published online June 5, 2008
Diabetes Care 31:1864-1866, 2008
DOI: 10.2337/dc08-0558
© 2008 by the American Diabetes Association
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Pathophysiology/Complications
Original Research

Oxidation, Type 2 Diabetes, and Coronary Heart Disease: A Complex Interaction

Findings from a population-based study

Saverio Stranges, MD, PHD1,2, Joan M. Dorn, PHD2, Richard P. Donahue, PHD2, Richard W. Browne, PHD3, Jo L. Freudenheim, PHD2, Kathleen M. Hovey, MSC2 and Maurizio Trevisan, MD, MSC2

1 Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, U.K.
2 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York
3 Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York

Corresponding author: Saverio Stranges, s.stranges{at}warwick.ac.uk

OBJECTIVE—The purpose of this study was to analyze the interrelationship among oxidation, myocardial infarction (MI), and type 2 diabetes in a population-based case-control study of MI.

RESEARCH DESIGN AND METHODS—Participants were 1,709 individuals from western New York: 257 women and men with incident MI and 1,452 healthy control subjects (aged 35–70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was determined by self-reported history of medical diagnosis.

RESULTS—In multivariate analyses, there was no significant difference in TBARS levels between case and control subjects in both sexes. In subgroup analyses by diabetes status, diabetic subjects, regardless of MI status, exhibited significantly higher TBARS values than nondiabetic subjects. For diabetic women, TBARS values were 1.84 and 1.83 nmol/ml for case and control subjects, respectively. Values for nondiabetic women were 1.29 and 1.31 nmol/ml, respectively. In diabetic men, values were 1.65 and 1.97 nmol/ml for case and control subjects, respectively. Values for nondiabetic men were 1.36 and 1.36 nmol/ml, respectively.

CONCLUSIONS—Whereas type 2 diabetes may be an important correlate of lipid peroxidation, clinical coronary heart disease may not.


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