Diabetes Care
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Diabetes Care 31:S284-S289, 2008
DOI: 10.2337/dc08-s269
© 2008 by the American Diabetes Association
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Section III: Obesity-The Rising Epidemic
Original Article

Can Gut Hormones Control Appetite and Prevent Obesity?

Owais B. Chaudhri, PHD, Katie Wynne, PHD and Stephen R. Bloom, MD, DSC

From the Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London, U.K

Address correspondence and reprint requests to Professor S.R. Bloom, Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Rd., London W12 0NN, U.K. E-mail: s.bloom{at}imperial.ac.uk

The current obesity epidemic is fuelled by the availability of highly palatable, calorie-dense food, and the low requirement for physical activity in our modern environment. If energy intake exceeds energy use, the excess calories are stored as body fat. Although the body has mechanisms that act to maintain body weight over time, they primarily defend against starvation and are less robust in preventing the development of obesity. Knowledge of this homeostatic system that controls body weight has increased exponentially over the last decade and has revealed new possibilities for the treatment of obesity and its associated comorbidities. One therapeutic target is the development of agents based on the gastrointestinal hormones that control appetite. This review discusses the hormones oxyntomodulin, peptide YY, glucagon-like peptide 1, pancreatic polypeptide, and ghrelin and their emerging potential as anti-obesity treatments.

Abbreviations: CNS, central nervous system • DPP-IV, dipetidyl peptidase IV • GI, gastrointestinal • GLP, glucagon-like peptide • OXM, oxyntomodulin • PYY, peptide YY


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Copyright © 2008 by the American Diabetes Association.