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Diabetes Care, Vol 5, Issue 2 97-100, Copyright © 1982 by American Diabetes Association

ARTICLES

Risk factors associated with severe proliferative retinopathy in insulin-dependent diabetes mellitus

HJ Bodansky, AG Cudworth, PL Drury and EM Kohner

The natural history of disease and suspected risk factors for bad prognosis were investigated in 40 subjects with insulin-dependent diabetes mellitus who had severe retinopathy and in 22 patients with a similar duration of diabetes without evidence of complications. The retinopathy group showed a marked excess of men (ratio 2:1). Examination of the data in the literature also showed a striking excess of men, 61% (P less than 0.001) in patients with insulin-dependent diabetes and severe microvascular disease. In addition, proliferative retinopathy was found to have significant associations with current poor diabetic control, hypertension, and previous treatment with once-daily insulin regimens, particularly with protamine zinc insulin.
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