Diabetes Care
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Diabetes Care, Vol 5, Issue 4 433-437, Copyright © 1982 by American Diabetes Association

ARTICLES

Induced basal normoglycemia and altered platelet aggregation in non-insulin-dependent diabetes

RJ Evans, J Lane, RR Holman and RC Turner

Non-insulin-dependent diabetic subjects had abnormally raised in vitro platelet aggregation rates to collagen or ristocetin when thought to be "well-controlled" on diet alone but shown to have raised basal plasma glucose levels. Basal normoglycemia, induced with either ultralente insulin or chlorpropamide, was associated with a significant reduction of the enhanced platelet aggregation rates to normal. Some sulfonylurea drugs have been reported to have specific anti-platelet aggregatory properties, but the degree of plasma glucose control is probably more relevant.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1982 by the American Diabetes Association.