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Diabetes Care Publish Ahead of Print published online ahead of print July 20, 2007
DOI: 10.2337/dc07-0922
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Original Research

Carotid intima-media thickness in pediatric type 1 diabetes patients

Rocio Rabago Rodriguez, MDa, Rita A. Gómez-Díaz, MDd, Janet Tanus Haj, MDc, Francisco Jose Avelar Garnica, MDc, Eleazar Ramirez Soriano, MDa, Elisa Nishimura Meguro, MDa, Carlos A. Aguilar-Salinas, MDb and Niels H. Wacher, MD, PhDd

aServicio de Endocrinología. UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico city. México
bDepartamento de Endocrinología y Metabolismo. Instituto Nacional de Ciencias Médicas y Nutrición. Mexico City. México
cServicio de Radiodiagnóstico and
dUnidad de Investigación Médica en Epidemiología Clínica UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City. México

ritagomezdiaz{at}netscape.net

ABSTRACT

Objective:To compare the carotid artery intima-media thickness in type 1 diabetes patients against healthy controls matched for age, gender, height and body mass index.

Research Design and Methods:The evaluation consisted in anthropometric measurements, biochemical parameters and a carotid Doppler and real-time ultrasound (in which the cIMT, the peak systolic velocity (PSV) and the end diastolic velocity (EDV) were measured using standardized procedures.

Results:52 patients and 47 control subjects were included. No significant differences existed in the characteristics between cases and controls (mean age 11.8± 3.1 vs 11.8± 2.8 years, weight 42.2± 15.3 vs 44.2± 14.4 kg, height 1.45 ± 0.15 vs 1.47± 0.15mts, BMI 19.3± 3.2vs 19.9± 4.4, systolic blood pressure 99.1± 9.9vs 99.6± 9 mmHg and diastolic blood pressure 63± 6.4 vs 62.0± 5.7 mmHg, respectively). The duration of diabetes was 4.8 ±3.2 years (range 6-144 months) The mean HbA1c was 8.6 ±1.6 %. A significantly higher cIMT was found in the patients with type 1 diabetes (0.463± 0.04 mm vs 0.441± 0.04 (p=0.001)). In contrast both PSV 107.1± 22.8 vs 119.3 ± 19.2 (p<0.005) and EDV 28.4± 6.0 vs 33.0± 7.0 (p<0.001) were higher in the control subjects.

Conclusions:Type 1 diabetes is associated with higher cIMT and decreased flow velocities in a pediatric population.


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