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Diabetes Care Publish Ahead of Print published online ahead of print January 30, 2008
DOI: 10.2337/dc07-2101
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Original Research

C-REACTIVE PROTEIN IN RELATION TO THE DEVELOPMENT OF MICROALBUMINURIA IN TYPE 1 DIABETES: THE OXFORD REGIONAL PROSPECTIVE STUDY

M. Loredana Marcovecchio, MD1,,2, Cosimo Giannini, MD2, Barry Widmer, BSc1, R. Neil Dalton, PhD3, Stefano Martinotti, MD4, Francesco Chiarelli, MD2 and David B. Dunger, MD1

1University Department of Paediatrics, Cambridge, UK
2University Department of Paediatrics and
4Department of Pathology, Chieti, Italy
3WellChild Laboratory, Evelina Children's Hospital, London, UK

dbd25{at}cam.ac.uk

ABSTRACT

Objectives: To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes (T1D) in relation to the development of microalbuminuria (MA).

Research Design and Methods: Hs-CRP was measured in 329 blood samples collected from 49 subjects with T1D with MA and 49 normoalbuminuric subjects matched for age, gender and duration of diabetes.

Results: In subjects developing MA a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (p=0.003, age-adjusted p=0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (1.9[0.2–9.8] vs 1.1[0.2–6.4]mg/L; p=0.02; adjusted p=0.036).

Conclusions: In this population of young subjects with T1D, there was a significant increase in hs-CRP levels after the onset of MA, probably reflecting a general state of inflammation.


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