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Assessment of Aortic Pulse Wave Velocity and Cardiac Diastolic Function in Subjects With and Without the Metabolic Syndrome

^aDepartments of Radiology
^bGeneral Internal Medicine and Endocrinology
^cMedical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands

S.D.Roes{at}lumc.nl

ABSTRACT

Objective: The influence of lipid and glucose metabolism in the metabolic syndrome (MS) on aortic pulse wave velocity (PWV) and left ventricular (LV) diastolic function was evaluated using magnetic resonance imaging (MRI).

Research Design and Methods: Aortic PWV and LV diastolic function were assessed using MRI in 32 subjects with (n=16) and without the MS (n=16), matched for age, waist circumference and blood pressure. The groups were compared with the unpaired t-test or Mann-Whitney U-test and linear regression analysis was applied.

Results: Aortic PWV was increased and LV diastolic function was decreased in subjects with compared to subjects without the MS. HDL-cholesterol was independently associated with aortic PWV (R=–0.470, p<0.01) and LV diastolic function (R=–0.421, p=0.02).

Conclusions: Increased aortic PWV and decreased LV diastolic function is observed in subjects with the MS, regardless of blood pressure. Moreover, HDL-cholesterol is independently associated with aortic PWV and LV diastolic function.

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