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Diabetes Care Publish Ahead of Print published online ahead of print April 21, 2008
DOI: 10.2337/dc08-0385
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Original Research

Association of 1,5-Anhydroglucitol and 2-Hour Postprandial Blood Glucose in Type 2 Diabetic Patients

Christoph Stettler, MD1,,2, Matthias Stahl, MD3, Sabin Allemann, PhD1,,2, Peter Diem, MD1, Kurt Schmidlin, DMD2, Marcel Zwahlen, PhD2, Walter Riesen, PhD4, Ulrich Keller, MD5 and Emanuel Christ, MD1

1Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Bern, Switzerland
2Institute of Social and Preventive Medicine, University of Bern, Switzerland
3Department of Internal Medicine, Cantonal Hospital, Olten, Switzerland
4Institute of Clinical Chemistry, Kantonsspital, St. Gallen, Switzerland
5Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel, Switzerland

christoph.stettler{at}insel.ch

ABSTRACT

Objective: To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-hour postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.

Research Design and Methods: In 55 patients, self-measured postprandial blood glucose values were correlated with 1,5-AG values over pre-specified preceding time periods (3 days, 1 week, weekly up to 12 weeks).

Results: The correlation coefficients were –0.34 (p<0.05) for postprandial glucose values in the preceding three days, –0.38 (p<0.001) for values during the week before a visit, and –0.40 (p<0.001) for the values obtained two weeks preceding the measurement of 1,5-AG. Correlations declined for time periods of ≥ 2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time-dependency of the correlation of HbA1c and fasting or postprandial glucose.

Conclusions: 1,5-AG best reflected the 2-hour postprandial glucose values of the two previous weeks.


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Copyright © 2008 by the American Diabetes Association.