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Diabetes Care 24:969-970, 2001
© 2001 by the American Diabetes Association, Inc.

Letters: Comments and Responses
Letter

Low Total Plasma Homocysteine Concentrations in Patients With Type 1 Diabetes

Mario Cotellessa, MD1, Giuseppe Minniti, MS1, Roberto Cerone, MD1, Francesca Prigione, MD1, Maria Grazia Calevo, MS2 and Renata Lorini, MD1

1 Department of Pediatrics
2 Service of Epidemiology and Biostatistics-Scientific Direction, University of Genoa, G. Gaslini Institute, Genoa, Italy

We read with great interest the recent article by C. Pavia et al. (1) on total homocysteine (tHcy) and its modifying vitamin factors (folates and vitamins B12 and B6) in adolescents with type 1 diabetes. The authors studied the possible relationship between hyperhomocysteinemia in type 1 diabetes and duration of disease, degree of metabolic control, presence of microalbuminuria, alterations in fundus oculi, and chronic lymphocytic thyroiditis.

Numerous studies clearly demonstrate that mild hyperhomocysteinemia is strongly related to vascular diseases (2,3). Patients with diabetes often develop premature vascular disease. In type 2 diabetes, increased plasma concentrations of tHcy were . . . [Full Text of this Article]

FOOTNOTES

References


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Copyright © 2001 by the American Diabetes Association.