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Diabetes Care 25:2112-2113, 2002
© 2002 by the American Diabetes Association, Inc.

Letters: Observations
Letter

The Role of Hemochromatosis C282Y and H63D Gene Mutations in Type 2 Diabetes

Findings from the Rotterdam Study and meta-analysis

Omer T. Njajou, PHD1, Behrooz Z. Alizadeh, MD1, Norbert Vaessen, MD, PHD1,2, Jeannete Vergeer, BSC1, Jeannine Houwing-Duistermaat, PHD1, Albert Hofman, MD, PHD1, Huibert A.P. Pols, MD, PHD1,2 and Cornelia M. van Duijn, MD, PHD1

1 Genetic Epidemiology Unit, Department of Epidemiology & Biostatistics, Rotterdam, the Netherlands
2 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands

The first 20% of the full text of this article appears below.

Diabetes is a disease commonly found in patients with hemochromatosis (1). The hemochromatosis C282Y and H63D mutations in the HFE gene are associated with increased iron stores (2), which in turn are associated with glucose intolerance and insulin resistance (3). Whether these HFE mutations play an important role in the pathogenesis of type 2 diabetes is still a matter of controversy.

We have studied the frequencies of the C282Y and H63D mutations in 254 subjects with glucose intolerance, 220 patients with type 2 diabetes, and 595 normoglycemic individuals (control subjects), all derived from a population-based . . . [Full Text of this Article]


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