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Diabetes Care 26:3188-3189, 2003
© 2003 by the American Diabetes Association, Inc.

Letter: Observations

Predictive Value of Autoantibodies to IA-2 for Insulin Requirements in Japanese Subjects With Type 1 Diabetes

Tsuguhito Ota, MD, PHD1, Toshinari Takamura, MD, PHD1, Yukihiro Bando, MD, PHD2, Rika Usuda, MD, PHD3 and Yukihiro Nagai, MD, PHD1

1 Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
2 Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan
3 Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan

Address correspondence to Toshinari Takamura, MD, PhD, Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan. E-mail: tt@medf.m.kanazawa-u.ac.jp

The first 20% of the full text of this article appears below.

GAD autoantibodies (GADAs) are frequently detected before the onset of diabetes and indicate the development of insulin dependency (1). Phosphatase-like protein IA-2 antibodies (IA-2As) in combination with GADA have been shown to improve the positive predictive value for type 1 diabetes (2). However, the presence of IA-2A and its clinical usefulness in Japanese type 1 diabetic patients have not been fully determined. Here we report the significance of serum antibodies to IA-2A and GADA to predict the insulin requirement in Japanese patients with type 1 diabetes.

We studied 101 Japanese patients with type . . . [Full Text of this Article]


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Copyright © 2003 by the American Diabetes Association.