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Type 1 Diabetes and Multiple Sclerosis

Together at last

¹ Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania
² Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
³ Department of Internal Medicine, Ospedale S. Michele, Cagliari, Sardinia, Italy

Address correspondence to Dr. Janice Dorman, A533 Crabtree Hall, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261. E-mail: jansdorman@aol.com

The first 20% of the full text of this article appears below.

Last year, Marrosu et al. (1) reported an increased prevalence of type 1 diabetes among Sardinian individuals with multiple sclerosis and their first-degree relatives. The study was accompanied by a commentary (2) indicating that these autoimmune disorders were "an unlikely alliance" because the HLA haplotype that increases risk for multiple sclerosis (DRB1*15-DQA1*0102-DQB1*0602) protects against type 1 diabetes. To the authors’ knowledge, there have been no published studies of an increased risk of multiple sclerosis for individuals with type 1 diabetes or their families.

Could the association between type 1 diabetes and multiple sclerosis be unique to Sardinia, where the rates of these two disorders . . . [Full Text of this Article]

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