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Deficiency in the Detection of Microalbuminuria by Urinary Dipstick in Diabetic Patients

¹ Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
² Endocrine Unit, Department of Medicine, University of Melbourne, Austin & Repatriation Medical Center, Heidelberg, Victoria, Australia

Address correspondence to Dr. Wayne D. Comper, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria, Australia 3800. E-mail: wayne.comper@med.monash.edu.au

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Microalbuminuria is considered a marker of diabetic nephropathy. Early detection of microalbuminuria allows for early intervention with the goal of delaying the onset of overt diabetic nephropathy.

The aim of this study was to compare the analysis of urinary albumin and creatinine by both Microalbustix and Clinitek microalbumin urinary dipsticks compared with high-performance liquid chromatography (HPLC) analysis.

Diabetic patients attending the Endocrine Clinic at Austin & Repatriation Medical Center, Heidelberg, Australia, were studied (56% normoalbuminuric, 34% microalbuminuric, and 10% macroalbuminuric by immunoturbidimetry). Albumin and creatinine concentrations were determined in 24-h urine samples by Microalbustix and Clinitek microalbumin dipsticks using a Clinitek 50 Autoanalyzer (Bayer, Elkhart, IN) and by HPLC, as previously described (1). Urinary creatinine concentration was also determined using a Hitachi 971 Autoanalyzer.

Using an upper limit of normal of <30 mg/l for albumin concentration, 56 of 115 and 48 . . . [Full Text of this Article]

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				S. Selgren Deficiency in the Detection of Microalbuminuria by Urinary Dipstick in Diabetic Patients: Response to Comper et al. Diabetes Care, September 1, 2004; 27(9): 2283 - 2284. [Full Text] [PDF]