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Diabetes Care 26:1942-1943, 2003
© 2003 by the American Diabetes Association, Inc.

Letters: Observations
Letter

Multiple Tumors in Mitochondrial Diabetes Associated With tRNALeu(UUR) Mutation at Position 3264

Yoshihiko Suzuki, MD1,3,4, Susumu Suzuki, MD2, Matsuo Taniyama, MD3, Taro Muramatsu, MD4, Shigeo Ohta, PHD5, Yoshitomo Oka, MD2, Yoshihito Atsumi, MD1 and Kempei Matsuoka, MD1

1 Saiseikai Central Hospital, Tokyo, Japan
2 Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan
3 Fujigaoka Hospital, Showa University, Kanagawa, Japan
4 Department of Neuropsychiatry, Keio University, Tokyo, Japan
5 Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kanagawa, Japan

The first 20% of the full text of this article appears below.

In 1997, we reported the first identified case of mitochondrial diabetes caused by a T-to-C transition at position 3264 (1). The proband was a 64-year-old man. His family tree revealed maternally inherited diabetes. He had diabetes, cerebellar ataxia, hearing loss, olfactory dysfunction, bilateral facial nerve palsy, oculomotor palsy, and cervical lipoma. Heteroplasmy of the 3264 mutation, maternal inheritance of diabetes, absence of 3264 mutation in control subjects, and . . . [Full Text of this Article]


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Copyright © 2003 by the American Diabetes Association.