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Diabetes Care 27:1838-1839, 2004
© 2004 by the American Diabetes Association, Inc.

Letters: Observations

Definition of Microalbuminuria in First-Morning and Random Spot Urine in Diabetic Patients

Tetsuya Babazono, MD, PHD1, Chieko Takahashi, MD, PHD1,2 and Yasuhiko Iwamoto, MD, PHD3

1 Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
2 Department of Food Science and Human Nutrition, Tokyo Metropolitan College, Tokyo, Japan
3 Department of Medicine, Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

Address correspondence to Tetsuya Babazono, MD, PhD, Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women’s Medical University School of Medicine, 8-1 Kawadacho, Shinjukuku, Tokyo 162-8666, Japan. E-mail: babazono@dmc.twmu.ac.jp

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Measurement of albumin excretion in a 24-h urine collection has long been the "gold standard" for quantitative evaluation of albuminuria in diabetic patients; however, collection errors due to improper timing and missed samples may lead to significant over- and underestimation of albuminuria. For convenience and consistency, the American Diabetes Association (1) and the National Kidney Foundation (2) have recently recommended measurement of albumin-to-creatinine ratio (ACR) in a random spot urine collection for diagnosis of microalbuminuria. Microalbuminuria is diagnosed if ACR ranges between 30 and 300 mg/g creatinine. The guidelines recommended using a first-morning sample because . . . [Full Text of this Article]


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Copyright © 2004 by the American Diabetes Association.