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© 2005 by the American Diabetes Association, Inc.
Pathophysiology/Complications |
Hepatitis C Virus Infection
Evidence for an association with type 2 diabetes
1 Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
2 Rheumatology Unit, Department of Internal Medicine, University of Modena, Modena, Italy
3 Division of Medicine, S. Chiara Hospital, Pisa, Italy
4 Department of Biological and Environmental Sciences, University of Sannio, Benevento, Italy
Address correspondence and reprint requests to Alessandro Antonelli, MD, Department of Internal Medicine, University of Pisa, School of Medicine, via Roma, 67, I-56100, Pisa, Italy. E-mail: a.antonelli@med.unipi.it
Abbreviations: HBV, hepatitis B virus • HCV, hepatitis C virus
| The first 20% of the full text of this article appears below. |
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INTRODUCTION |
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An increased prevalence of type 2 diabetes and impaired glucose tolerance has been consistently found in liver cirrhosis from any cause (1–3). Less clear is whether hepatitis C virus (HCV) infection is associated with type 2 diabetes in the absence of cirrhosis. Several reports have claimed a specific association between HCV infection and type 2 diabetes, but in most instances, patients were a mixture of cases with cirrhosis and hepatitis (4–6). Two clinic-based studies found an excess of type 2 diabetes in noncirrhotic HCV+ (NC-HCV+) patients compared with patients with chronic hepatitis of other origin (7–9), but another large study could not detect it (10). Furthermore, one clinic-based small study found a specific association with type 2 diabetes in NC-HCV+ patients (11) compared with a general population sample.
The aim of this study was to establish the prevalence and clinical phenotype of type 2 diabetes in a large series of NC-HCV+ patients. A sample of the general population or patients with hepatitis B virus (HBV)-related noncirrhotic chronic hepatitis (NC-HBV+) was used as control subjects.
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RESEARCH DESIGN AND METHODS |
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From January 1995 to December 2001, 564 NC-HCV+ patients were consecutively examined at our center (none had been previously treated with interferon). Diagnosis of HCV infection was based on abnormal serum aminotransferases levels of >6 months’ duration and positive
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RESULTS |
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CONCLUSIONS |
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