HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pittas, A. G. Articles by Roberts, S. B. Search for Related Content PubMed PubMed Citation Articles by Pittas, A. G. Articles by Roberts, S. B. Social Bookmarking                What's this?

A Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults With High Insulin Secretion but Not in Overweight Adults With Low Insulin Secretion in the CALERIE Trial

¹ Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts
² Energy Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
³ Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts

Address correspondence and reprint requests to Anastassios G. Pittas, M.D., Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, 750 Washington St., #268, Boston, MA 02111. E-mail: apittas@tufts-nemc.org

Abbreviations: HOMA-IR, homeostasis model assessment of insulin resistance • INS-30, insulin value at 30 min

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Lifestyle changes, in particular reducing energy intake, are the cornerstone of current approaches to weight loss and prevention of type 2 diabetes. However, there is currently no consensus that one dietary regimen is more effective than another for weight loss (1) or whether particular diets work better for identifiable groups of individuals. There is evidence, however, to suggest that both insulin resistance and insulin secretion play a role in body weight regulation (2–12). Therefore, dietary factors such as the dietary glycemic load (glycemic load = glycemic index [GI] x available carbohydrate amount) that influence these parameters may theoretically interact with subject-specific characteristics of glucose-insulin dynamics to influence the effect of different hypocaloric diets on weight loss or maintenance (13,14). Weight loss studies using the concept of the dietary glycemic index or glycemic load have shown conflicting results for heterogeneous groups of individuals (15–21).

In a 6-month controlled feeding trial in healthy overweight adults with normal glucose tolerance, we tested the hypothesis that individuals with higher insulin secretion lose more weight when randomized to a low–glycemic load diet compared with a high–glycemic load diet.

	RESEARCH DESIGN AND METHODS

 
This study was performed as part of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial at the Human Nutrition Research Center on Aging at Tufts University with approval from the Tufts-New England Medical Center Human Investigation Review Committee. Written informed consent was . . . [Full Text of this Article]

	RESULTS

 

	CONCLUSIONS

 

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. Marsh and J. Brand-Miller State of the Art Reviews: Glycemic Index, Obesity, and Chronic Disease American Journal of Lifestyle Medicine, April 1, 2008; 2(2): 142 - 150. [Abstract] [PDF]

				J. Brand-Miller Effects of glycemic load on weight loss in overweight adults Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1249 - 1250. [Full Text] [PDF]

				S. K. Das and S. B Roberts Reply to J Brand-Miller Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1250 - 1250. [Full Text] [PDF]

				T. You, W. E. Sonntag, X. Leng, and C. S. Carter Lifelong Caloric Restriction and Interleukin-6 Secretion From Adipose Tissue: Effects on Physical Performance Decline in Aged Rats J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2007; 62(10): 1082 - 1087. [Abstract] [Full Text] [PDF]

				R. Sichieri, A. S Moura, V. Genelhu, F. Hu, and W. C Willett An 18-mo randomized trial of a low-glycemic-index diet and weight change in Brazilian women Am. J. Clinical Nutrition, September 1, 2007; 86(3): 707 - 713. [Abstract] [Full Text] [PDF]

				C. B. Ebbeling, M. M. Leidig, H. A. Feldman, M. M. Lovesky, and D. S. Ludwig Effects of a Low-Glycemic Load vs Low-Fat Diet in Obese Young Adults: A Randomized Trial JAMA, May 16, 2007; 297(19): 2092 - 2102. [Abstract] [Full Text] [PDF]

				K. C Maki, T. M Rains, V. N Kaden, K. R Raneri, and M. H Davidson Effects of a reduced-glycemic-load diet on body weight, body composition, and cardiovascular disease risk markers in overweight and obese adults Am. J. Clinical Nutrition, March 1, 2007; 85(3): 724 - 734. [Abstract] [Full Text] [PDF]

				M. A Pereira Reply to EJ Mayer-Davis Am. J. Clinical Nutrition, March 1, 2007; 85(3): 922 - 923. [Full Text] [PDF]

				M. A Pereira Weighing in on glycemic index and body weight. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 677 - 679. [Full Text] [PDF]