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Diabetes Care 28:756-757, 2005
© 2005 by the American Diabetes Association, Inc.

Letters: Observations

Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects

The DIAD study

Caroline G. Baxter, MB1, Nicolas A. Boon, MD1 and James D. Walker, MD2

1 Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland
2 Medical Unit, St . John’s Hospital, Livingston, Scotland

Address correspondence to James D. Walker, Medical Unit, St. John’s Hospital, Livingston, EH54 6PP, Scotland, U.K. E-mail: james.walker@wlt.scot.nhs.uk

The first 20% of the full text of this article appears below.

We were impressed by the results of the Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects (DIAD) study (1), which found that silent myocardial ischemia (SMI) was present in 22% of a large cohort of asymptomatic patients with type 2 diabetes and that the strongest predictor for abnormal cardiac tests was an abnormal Valsalva test. We have also found that autonomic function predicts SMI but that abnormal sympathetic, rather than parasympathic, tests are predictive.

We selected 12 patients with type 2 diabetes and 12 nondiabetic patients with documented exercise-induced electrocardiogram (ECG) changes (Bruce protocol) and angiographically proven coronary artery disease from the cardiac catheterization database of . . . [Full Text of this Article]


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