© 2005 by the American Diabetes Association, Inc.
Lipids and Glucose in Type 2 Diabetes: What About the ß-Cell and the Mitochondria?Response to Eldor and Raz
1 Temple University Health Science Center, General Clinical Research Center, Philadelphia, Pennsylvania Address correspondence to Dr. Guenther Boden, MD, Temple University Health Science Center, General Clinical Research Center, North Broad St., 4W, Philadelphia, PA 19140. E-mail: guenther.boden@tuhs.temple.edu
Drs. Eldor and Raz (1) assert that "high levels of FFAs [free fatty acids] have a detrimental effect on ß-cell survival and insulin secretion." We agree, but only in relation to patients who have dysfunctional ß-cells, i.e., patients with pre-diabetes, impaired glucose tolerance, or type 2 diabetes (25).
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