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Diabetes Care 28:1225-1227, 2005
© 2005 by the American Diabetes Association, Inc.

Metabolic Syndrome/Insulin Resistance Syndrome/Pre-Diabetes
Brief Report

Glucose-Induced Insulin Secretion in Dyslipidemic and Normolipidemic Patients With Normal Glucose Tolerance

Christophe Binnert, PHD1, Myriam Genoud, MD2, Gérald Seematter, MD1, Assia Fekirini, MD1, Vincent Mooser, MD, PHD3, Gérard Waeber, MD, PHD2 and Luc Tappy, MD1,4

1 Department of Physiology, Medical School, University of Lausanne, Lausanne, Switzerland
2 Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
3 GlaxoSmithKline, Collegeville, Pennsylvania
4 Division of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland

Address correspondence and reprint requests to Prof. L. Tappy, Département de physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland. E-mail: luc.tappy@unil.ch

The first 20% of the full text of this article appears below.


   INTRODUCTION
 
The metabolic syndrome is highly prevalent in industrialized countries, where it represents a major public health burden due to the associated high risk of diabetes and cardiovascular disorders (1,2). High plasma triglyceride and low HDL cholesterol are prominent features of this syndrome (2,3). Large epidemiological studies have shown associations with both insulin resistance and low insulin secretion (4). The aim of this study was to evaluate whether the alterations of blood lipid, observed in the metabolic syndrome, are associated with alterations of insulin sensitivity or secretion in subjects with normal glucose tolerance. Glucose homeostasis was evaluated during a two-step hyperglycemic clamp in a group of dyslipidemic patients and in a group of normolipemic subjects of similar age and body weight. Subjects were studied after short-term administration of dexamethasone to evaluate reciprocal changes in insulin secretion and insulin sensitivity (5,6,7,8).


   RESEARCH DESIGN AND METHODS
 
Twenty dyslipidemic subjects (13 men and 7 women) with BMI >27 kg/m2 but having normal glucose tolerance, as documented by a standard oral glucose tolerance test (fasting glycemia 94 ± 7 mg/dl, 2-h glycemia 95 ± 17 mg/dl) (9), were selected for the study. They had a mean . . . [Full Text of this Article]


   RESULTS
 

   CONCLUSIONS
 

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Copyright © 2005 by the American Diabetes Association.