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Comparison of Clinical and Laboratory Characteristics Between Adult-Onset Type 1 Diabetes and Latent Autoimmune Diabetes in Adults

From the Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil

Address correspondence and reprint requests to Pedro Weslley Souza Rosário, Centro de Estudos e Pesquisa da Clinica de Endocrinologia e Metabologia (CEPCEM), Av. Francisco Sales, 1111, 5 andar Ala D, Santa Efigênia, CEP 30150-221, Belo Horizonte, MG, Brasil. E-mail: pedrorosario@globo.com

Abbreviations: GADA, GAD antibody • ICA, islet cell antibody • LADA, latent autoimmune diabetes in adults • TPOA, anti-TPO antibody

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Although they do not initially require insulin, diabetic adults presenting autoantibodies against ß-cells (anti-GAD antibody [GADA] and anti–islet cell antibody [ICA]) more rapidly develop the need for insulinization, a fact characterizing latent autoimmune diabetes in adults (LADA) (1,2). Differences between LADA and type 2 diabetes (3–6) and between children and adults with type 1 diabetes (7) have been reported. In contrast, few studies are available comparing type 1 diabetes diagnosed during adulthood with LADA, with the results not being consistent (4,5,8). Therefore, the aim of the present study was to investigate clinical and laboratory parameters in patients with LADA compared with patients with adult-onset type 1 diabetes.

	Research Design and Methods

 
Among the diabetic adults (age at diagnosis >35 years) seen at our service and investigated with GADA upon diagnosis (no routine ICA analysis was performed) (2), 54 patients with LADA (individuals not requiring insulin for at least 1 year after diagnosis and positive for GADA) (1,2. . . [Full Text of this Article]

	Results

 

	Conclusions

 

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