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Body Iron Stores Are Increased in Overweight and Obese Women With Polycystic Ovary Syndrome

¹ Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain
² Department of Molecular Genetics, Hospital Ramón y Cajal, Madrid, Spain

Address correspondencereprint requests to Héctor F. Escobar-Morreale, Department of Endocrinology, Hospital Ramón y Cajal, Carretera de Colmenar km 9'1, Madrid E-28034, Spain. E-mail: hescobarm.hrc@salud.madrid.org

Abbreviations: CRP, C-reactive protein • PCOS, polycystic ovary syndrome

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Increased body iron stores are associated with insulin resistance and type 2 diabetes. In conceptual agreement, increased serum ferritin levels are positively associated with the prevalence of the metabolic syndrome in men and adult pre- and postmenopausal women (1) and with an increased risk of type 2 diabetes in both men (2) and women (2, 3). Given that insulin resistance and an increased risk of type 2 diabetes are frequent in patients with polycystic ovary syndrome (PCOS) (4, 5), we hypothesize that body iron stores might be especially increased in these women.

	RESEARCH DESIGN AND METHODS

 
We studied 78 patients with PCOS and 43 nonhyperandrogenic control subjects matched for BMI and degree of obesity (6). Women were phenotyped to determine clinical, anthropometrical hormonal and metabolic variables as described previously (7). Serum ferritin and C-reactive protein (CRP) concentrations were measured by automated immunochemiluminescence (Immulite 2000 Ferritin and High Sensitivity CRP; Diagnostic Products, Los Angeles, CA) with lower limits of detection of 0.9 pmol/l and 0.1 mg/l, respectively. None of the women had a history of abnormal glucose tolerance or had taken insulin sensitizers in the previous 6 months. The ethics committee of Hospital Ramón y Cajal approved the study, and informed consent was obtained from all participants.

Data were analyzed by general linear model after ensuring a normal distribution of the variables by . . . [Full Text of this Article]

	RESULTS

 

	CONCLUSIONS

 

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				M. Luque-Ramirez, F. Alvarez-Blasco, J. I. Botella-Carretero, R. Sanchon, J. L. San Millan, and H. F. Escobar-Morreale Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses Diabetes Care, September 1, 2007; 30(9): 2309 - 2313. [Abstract] [Full Text] [PDF]

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