HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ladeia, A. M. Articles by Adan, L. Search for Related Content PubMed PubMed Citation Articles by Ladeia, A. M. Articles by Adan, L. Social Bookmarking                What's this?

Endothelial Dysfunction Is Correlated With Microalbuminuria in Children With Short-Duration Type 1 Diabetes

¹ Bahian Medical and Public Health School and Post-Graduate of Bahian Medical and Public Health School, Science Development Foundation of Bahia, Bahia, Brazil
² ECOIMAGEM, Ultrasound Laboratory, Salvador, Bahia, Brazil
³ Pediatrics Department, Federal University of Bahia School of Medicine, Salvador, Bahia, Brazil
⁴ Pediatric Unit, State of Bahia Center for Diabetes and Endocrinology (CEDEBA), Salvador, Bahia, Brazil

Address correspondence and reprint requests to A. M. Ladeia, Rua Altino S de Barros 241 s506 Itaigara, Salvador-BA, Brazil, CEP 41 810 570. E-mail: analadeia@uol.com.br

Abbreviations: FMD, flow-mediated dilatation • NOS, nitric oxide synthase

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Patients with diabetes have increased risk of developing atherosclerotic diseases (1). In type 1 diabetes, vascular complications are more frequently identified after the 5th year of the disease. Ultrasound assessment of endothelial function is a noninvasive method for detecting early structural and functional atherosclerotic process in the arterial wall. Impaired flow-mediated dilatation (FMD), an early marker of atherosclerosis, has been detected in children with family hypercholesterolemia (2) and diabetes (3). This study assessed the presence of endothelial dysfunction in children with type 1 diabetes and <5 years duration of the disease.

	RESEARCH DESIGN AND METHODS

 
This cross-sectional study included 18 randomly selected type 1 diabetic patients (13 boys) followed up at a public health assistance center, with disease duration of 2.9 ± 1.2 years (0.7–4.9 years) and without clinical evidence of vascular complications, and 14 healthy control subjects (7 boys) without chronic diseases or hypercholesterolemia, matched by age (±2 years) and BMI. Patients with retinopathy, hypertension, obesity, thyroid disease, and history of smoking were excluded. Laboratory data included fasting blood glucose, plasma lipids, HbA_1c (A1C), creatinine, TSH, and microalbuminuria.

After the subjects had been lying in supine position for 10 min in a stable- temperature room, the response to reactive hyperemia (FMD) was evaluated. The diameter of the brachial artery was measured in a longitudinal section (2–15 cm above the elbow) with a high-resolution vascular . . . [Full Text of this Article]

	RESULTS

 

	CONCLUSIONS

 

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. E. Schmieder, C. Delles, A. Mimran, J. P. Fauvel, and L. M. Ruilope Impact of Telmisartan Versus Ramipril on Renal Endothelial Function in Patients With Hypertension and Type 2 Diabetes Diabetes Care, June 1, 2007; 30(6): 1351 - 1356. [Abstract] [Full Text] [PDF]

				A. M. Ladeia, E. Stefanelli, C. Ladeia-Frota, A. Moreira, A. Hiltner, and L. Adan Association Between Elevated Serum C-Reactive Protein and Triglyceride Levels in Young Subjects With Type 1 Diabetes Diabetes Care, February 1, 2006; 29(2): 424 - 426. [Full Text] [PDF]