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Diabetes Care 28:2081-2082, 2005
© 2005 by the American Diabetes Association, Inc.

Letters: Observations

Transcutaneous Gases Determination in Diabetic Critical Limb Ischemia

Elio Melillo, MD1, Mauro Ferrari, MD1,2, Alberto Balbarini, MD1 and Roberto Pedrinelli, MD1

1 Dipartimento Cardio Toracico, Università di Pisa, Pisa, Italy
2 Dipartimento Chirurgia Vascolare, Università di Pisa, Pisa, Italy

Address correspondence to Roberto Pedrinelli, MD, Dipartimento Cardio Toracico, Università di Pisa, Via Paradisa 2, Pisa, Italy, 56100. E-mail: r.pedrinelli@med.unipi.it

The first 20% of the full text of this article appears below.

Transcutaneous oxygen tension (tcpO2) quantifies oxygen delivery through skin capillaries as a function of two main physiological variables, the effective rate of skin blood flow and skin resistance to oxygen permeation, represented mainly by stratum-corneum permeability (1). TcpO2 is an accepted measure of nutritive skin perfusion (1) and predicts the therapeutic outcome in critical limb ischemia (CLI) (2), a serious complication of type 2 diabetes, a disease characterized by the coexistence of macro- and microvascular alterations (3). Transcutaneous carbon dioxide tension (tcpCO2), another tensiometric parameter, is sensitive to severe limb ischemia (4) and correlates closely with HCO–3 depletion, H+ accumulation, and acidotic milieu (5). Thus, tcpCO2, by providing an indication of the local acid-base balance, might improve the clinical management of patients on CLI, but its prognostic potential in that context is unknown.

We addressed this issue in . . . [Full Text of this Article]


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Copyright © 2005 by the American Diabetes Association.