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Diabetes Care 28:2082, 2005
© 2005 by the American Diabetes Association, Inc.


Letters: Observations

Statin Neuropathy Masquerading as Diabetic Autoimmune Polyneuropathy

Tom Brooks Vaughan, MD and David S.H. Bell, MD

Address correspondence and reprint requests to Tom Brooks Vaughan, MD, Division of Endocrinology, University of Alabama School of Medicine, Faculty Office Tower, Suite 758, 510 20th St. S., Birmingham, AL 35294. E-mail: brooks@uab.edu

The first 20% of the full text of this article appears below.

Statin-induced neuropathy is increasingly described. Proposed mechanisms include an alteration in cholesterol synthesis, producing a disturbance in the cholesterol-rich neuronal membrane, or in the activity of ubiquinone (coenzyme Q10), a mitochondrial respiratory chain enzyme inhibited by statins leading to neuronal damage (1). The entire class is implicated, and both polyneuropathy and mononeuropathy have been described with improvement or even complete resolution occurring with cessation of therapy (1). In all cases, clinical improvement occurred soon after statins were discontinued, and in the absence . . . [Full Text of this Article]


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