HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ladeia, A. M. Articles by Adan, L. Search for Related Content PubMed PubMed Citation Articles by Ladeia, A. M. Articles by Adan, L. Social Bookmarking                What's this?

Association Between Elevated Serum C-Reactive Protein and Triglyceride Levels in Young Subjects With Type 1 Diabetes

¹ Bahian Medical and Public Health School and Post-Graduate of Bahian Medical and Public Health School, Science Development Foundation of Bahia, Bahia, Brazil
² LPC Clinical Pathology Laboratory, Bahia, Brazil
³ Pediatric Unit, State of Bahia Center for Diabetes and Endocrinology (CEDEBA), Bahia, Brazil
⁴ Department of Pediatrics, Federal University of Bahia School of Medicine, Bahia, Brazil

Address correspondence and reprint requests to A.M. Ladeia, Rua Altino S de Barros 241 s506 Itaigara, Salvador-BA, Brazil, CEP 41 810 570. E-mail: analadeia@uol.com.br

Abbreviations: CRP, C-reactive protein • hs-CRP, high-sensitivity CRP

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Cardiovascular disease is the major cause of mortality and morbidity in individuals with diabetes (1,2). Increased plasma concentrations of acute-phase proteins have been reported in adult patients with either type 2 (3,4) or type 1 (5,6) diabetes. However, there have been few studies to determine plasma high-sensitivity C-reactive protein (hs-CRP) levels in young diabetic patients (7,8). This study evaluated the levels of hs-CRP and their correlation with metabolic profile in very young patients with type 1 diabetes.

	RESEARCH DESIGN AND METHODS

 
This sectional study included 45 consecutive young patients (26 boys) who fulfilled the inclusion criteria (diagnosed as type 1 diabetic, followed up at a public health assistance center, serum creatinine level <1.3 mg/dl, and normal thyroid-stimulating hormone values) and 30 healthy subjects (12 boys) matched by age (±3 years) and BMI. Exclusion criteria were hypertension, overweight or obesity, smoking, any infection having been diagnosed during the previous 3 months, and treatment for inflammatory or chronic infectious disease.

Measurements of pulse rate, blood pressure, height and weight, and specific clinical examination of throat, eyes, nose, ears, skin, and feet were performed. Laboratory data included fasting blood glucose, HbA_1c (A1C), total cholesterol, HDL and LDL cholesterol, triglycerides, serum creatinine, thyroid-stimulating hormone, and hs-CRP. Hs-CRP was determined by nephelometry.

Differences in the means were evaluated by the Student’s t test. The hs-CRP data . . . [Full Text of this Article]

	RESULTS

 

	CONCLUSIONS

 

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?