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Diabetes Care 29:475-476, 2006
DOI: 10.2337/diacare.29.02.06.dc05-1925
© 2006 by the American Diabetes Association
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Letters: Comments and Responses

Influence of Glycemic Index/Load on Glycemic Response, Appetite, and Food Intake in Healthy Humans

Response to Ludwig and Roberts and to Wolever and Brand-Miller

Rita C.G. Alfenas, PHD1 and Richard D. Mattes, PHD2

1 Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, Brazil
2 Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana

Address correspondence to Richard D. Mattes, PhD, Purdue University, Department of Foods and Nutrition, Stone Hall, Room 212, 700 W. State St., West Lafayette, IN 47907-2059. E-mail: mattes@purdue.edu

The first 20% of the full text of this article appears below.

We are pleased to respond to the comments of Ludwig and Roberts (1) as well as Wolever and Brand-Miller (2). We will address the points raised by the former first.

Ludwig and Roberts state that we "conclude that the glycemic index values of individual foods do not predict glycemic response to mixed meals." Actually, we go beyond that and demonstrate that the glycemic index value of individual foods do not even reliably predict the glycemic response to that food alone. Indeed, Jenkins et al. (3) showed 15 years ago that the glycemic response to the gold-standard stimulus, glucose in water, depends on the timing of ingestion.

Second, Ludwig and Roberts state that "[b]ecause the observed glycemic response did not differ between diets, the lack of effect on appetite is not surprising." This assumes glucose or insulin is a key determinant of appetite. While both are correlated with hunger . . . [Full Text of this Article]


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Copyright © 2006 by the American Diabetes Association.