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Autologous Transplantation of Granulocyte Colony–Stimulating Factor–Mobilized Peripheral Blood Mononuclear Cells Improves Critical Limb Ischemia in Diabetes

Response to Huang et al.

Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova Medical School, Padova, Italy

Address correspondence to Gian Paolo Fadini, MD, Dipartimento di Medicina Clinica e Sperimentale, Divisione di Malattie del Metabolismo, Policlinico Universitario, Via Giustiniani, 2, 35100 Padova, Italy. E-mail: gianpaolofadini@hotmail.com

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Huang et al. (1), in their small seminal clinical trial of cellular therapy for critical limb ischemia in diabetic patients, did not include presence of diabetic retinopathy among their exclusion criteria. It is known that individuals with diabetes are subjected to poor blood vessel growth in ischemic hearts and limbs and increased angiogenesis in retinal complications. This so-called "diabetic paradox" has been attributed . . . [Full Text of this Article]

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This article has been cited by other articles:

				G. P. Fadini, S. Sartore, I. Baesso, M. Lenzi, C. Agostini, A. Tiengo, and A. Avogaro Endothelial progenitor cells and the diabetic paradox. Diabetes Care, March 1, 2006; 29(3): 714 - 716. [Full Text] [PDF]

				B. Zhou, P. Huang, and Z. C. Han Autologous Transplantation of Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood Mononuclear Cells Improves Critical Limb Ischemia in Diabetes: Response to Fadini and Avogaro Diabetes Care, February 1, 2006; 29(2): 479 - 480. [Full Text] [PDF]