DOI: 10.2337/dc05-2336 © 2006 by the American Diabetes Association
Favorable Effects of Early Insulin Secretion by Nateglinide on Postprandial Hyperlipidemia in Patients With Type 2 Diabetes
1 Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, Tokyo, Japan Address correspondence to Masumi Ai, MD, PhD, Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. E-mail: ai.vasc@tmd.ac.jp
Severe postprandial hyperlipidemia is observed in and substantially contributes to the progression of atherosclerosis in type 2 diabetic patients, especially those with insulin resistance and compensatory hyperinsulinemia (14). As with postprandial hyperglycemia, increased lipid levels in type 2 diabetic patients peak late, and the magnitude of the increase is greater than that seen in healthy people (2,4). To determine whether early insulin secretion by nateglinide can suppress postprandial hyperlipidemia in type 2 diabetic patients, 20 Japanese patients
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