Diabetes Care
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Diabetes Care 29:1180 2006
DOI: 10.2337/dc05-2336
© 2006 by the American Diabetes Association
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Letters: Observations

Favorable Effects of Early Insulin Secretion by Nateglinide on Postprandial Hyperlipidemia in Patients With Type 2 Diabetes

Masumi Ai, MD, PHD1, Akira Tanaka, MD, PHD2, Kyoko Ogita, MD1 and Kentaro Shimokado, MD, PHD1

1 Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, Tokyo, Japan
2 Department of Health and Nutrition, College of Human Environmental Studies, Kanto-gakuin University, Yokohama, Japan

Address correspondence to Masumi Ai, MD, PhD, Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. E-mail: ai.vasc@tmd.ac.jp

The first 20% of the full text of this article appears below.

Severe postprandial hyperlipidemia is observed in and substantially contributes to the progression of atherosclerosis in type 2 diabetic patients, especially those with insulin resistance and compensatory hyperinsulinemia (1–4). As with postprandial hyperglycemia, increased lipid levels in type 2 diabetic patients peak late, and the magnitude of the increase is greater than that seen in healthy people (2,4). To determine whether early insulin secretion by nateglinide can suppress postprandial hyperlipidemia in type 2 diabetic patients, 20 Japanese patients . . . [Full Text of this Article]


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