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Diabetes Care 29:1183 2006
DOI: 10.2337/dc05-0338
© 2006 by the American Diabetes Association
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Letters: Observations

Metformin-Induced Pancreatitis

A possible adverse drug effect during acute renal failure

Filippo Luca Fimognari, MD1,2, Andrea Corsonello, MD3, Ruggero Pastorell, MD1 and Raffaele Antonelli-Incalzi, MD2

1 Division of Internal Medicine, Leopoldo Parodi-Delfino Hospital, ALS Roma G, Colleferro, Rome, Italy
2 Division of Geriatrics, University Campus Biomedico of Rome, Rome, Italy
3 Division of Geriatrics, Istituto Nazionale Ricovero e Cura dell’ Anziano, Istituto di Ricovero e Cura a Carattere Scientifico, Cosenza, Italy

Address correspondence to Dr. Filippo L. Fimognari, Centro per la Salute dell’Anziano, University Campus Biomedico of Rome, Via dei Compositori 130, 00128, Rome, Italy. E-mail: filippo.fimognari@virgilio.it

The first 20% of the full text of this article appears below.

About 2% of episodes of acute pancreatitis are caused by drugs (1). Phenformin was repeatedly associated with acute pancreatitis (1), but only two case reports highlighted a possible causative role for metformin (2,3). In one case, acute pancreatitis occurred for the coexistence of correct metformin treatment and acute renal failure (2); in the other, metformin overdose was deemed responsible (3).

A 61-year-old woman with diabetes and hypercholesterolemia presented after 5 days of vomiting, followed by oliguria and epigastric pain. At . . . [Full Text of this Article]


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Copyright © 2006 by the American Diabetes Association.