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Diabetes Care 29:1987-1988, 2006
DOI: 10.2337/dc06-0838
© 2006 by the American Diabetes Association
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Letters: Comments and Responses

Multicentric, Randomized, Controlled Trial to Evaluate Blood Glucose Control by the Model Predictive Control Algorithm Versus Routine Glucose Management Protocols in Intensive Care Unit Patients

Response to Ligtenberg et al.

Johannes Plank, MD1, Jan Blaha, MD2, Jeremy Cordingley, MBBS3, Malgorzata E. Wilinska, PHD4, Ludovic J. Chassin, PHD4, Cliff Morgan, PHD3, Stephen Squire, BSC3, Martin Haluzik, PHD2, Jaromir Kremen, MD2, Stepan Svacina, PHD2, Wolfgang Toller, MD1, Andreas Plasnik, MD1, Martin Ellmerer, PHD1, Roman Hovorka, PHD4 and Thomas R. Pieber, MD1

1 Department of Internal Medicine, Medical University Hospital, Graz, Austria
2 1 Faculty of Medicine, Charles University, Prague, Czech Republic
3 Royal Brompton Hospital, London, U.K.
4 Cambridge University, Cambridge, U.K.

Address correspondence to Johannes Plank, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria. E-mail: johannes.plank@klinikum-graz.at

The first 20% of the full text of this article appears below.

We thank Ligtenberg et al. (1) for drawing attention to our study, which demonstrated the efficacy and safety of the model predictive control (MPC) algorithm in controlling glycemia in critically ill postsurgery patients (2). We agree that properly designed studies evaluating different treatment approaches are needed. Our contribution was to execute the first prospective multicenter comparison of insulin titration protocols aiming to achieve tight glucose control. We agree that the best feasible approach for a . . . [Full Text of this Article]


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Copyright © 2006 by the American Diabetes Association.