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Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes

From the National Public Health Institute, Helsinki, Finland

Address correspondence and reprint requests to Paul Knekt, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. E-mail: paul.knekt@ktl.fi

Abbreviations: 25OHD, 25-hydroxyvitamin D

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
It has been suggested that vitamin D reduces the risk of type 2 diabetes. The finding that vitamin D deficiency is associated with impaired ß-cell function and insulin resistance in animals (1,2) and humans (3,4) is in line with that hypothesis. In the only cohort study published, the intake of vitamin D supplements was inversely associated with the development of type 2 diabetes (5). Since vitamin D intake covers only a part of the total vitamin D available, the purpose of this study was to evaluate the prediction of serum 25-hydroxyvitamin D (25OHD) on subsequent type 2 diabetes incidence.

	RESEARCH DESIGN AND METHODS—

 
The study population, collected from 1978 to 1980 as part of the Mini-Finland Health Survey (6), consisted of 4,423 men and women aged 40–69 years. After exclusion of 247 individuals with type 2 diabetes at baseline (i.e., fasting plasma glucose >7.0 mmol/l on two occasions or >11.0 mmol/l on a single occasion) and 79 individuals with missing values of serum 25OHD, the final sample size was 4,097. Data on education, smoking, leisure-time exercise, and hypertension medication were collected in a health examination (6). Height, weight, and blood pressure were measured, and blood samples were collected and stored at . . . [Full Text of this Article]

	RESULTS—

 

	CONCLUSIONS—

 

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