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Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women: the Women’s Health Initiative Observational Study

Response to Song et al.

¹ Department of Medicine, University of Washington School of Medicine, Seattle, Washington
² International Diabetes Institute, Caulfield, Victoria, Australia

Address correspondence to Edward J. Boyko, MD, MPH, Seattle ERIC, 1100 Olive Way, Suite 1400, Seattle, WA 98101. E-mail: eboyko@u.washington.edu

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We read with interest the article (1) on the risk of incident diabetes in the Women’s Health Initiative Observational Study (WHI-OS) in relation to homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and β-cell function (HOMA-B). In this letter, we raise a number of issues that we believe require further clarification.

The aim of Song et al.’s study was "to prospectively examine the relations of HOMA ... with diabetes risk" (1). Why, then, are 766 women with a fasting glucose at baseline 126 mg/dl included in the analysis? Although these women were excluded from other analyses, it . . . [Full Text of this Article]

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				Y. Song and S. Liu Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women: the Women's Health Initiative Observational Study: Response to Boyko et al. Diabetes Care, November 1, 2007; 30(11): e111 - e111. [Full Text] [PDF]