DOI: 10.2337/dc07-1246 © 2007 by the American Diabetes Association
Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in ChildrenResponse to Nobili et al.
1 Social Medicine Department, University of Bristol, Bristol, U.K Address correspondence to Abigail Fraser, Social Medicine Department, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, U.K. E-mail: abigail.fraser@bristol.ac.uk
We read with interest the article by Nobili et al. (1), who reported results of a case-control study that demonstrated an association between intrauterine growth retardation (defined as small for gestational age [SGA]) and pediatric nonalcoholic streatohepatitis (nonalcoholic fatty liver disease [NAFLD]).
Nobili et al. (1) compared children with NAFLD with hospital control subjects. The choice of control subjects may result in an underestimate of the association between SGA and NAFLD if
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