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Relationship Between BMI and Age at Diagnosis of Type 1 Diabetes in a Mediterranean Area in the Period of 1990–2004

¹ Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic I, Universitari, Barcelona, Spain
² Endocrinology Unit, Hospital Germans Trias I Pujol, Badalona, Spain
³ Consell Assessor per a la Diabetis a Catalunya, Barcelona, Spain

Address correspondence and reprint requests to Dr I. Conget, Endocrinology and Diabetes Unit, Villarroel 170, 08036 Barcelona, Spain. E-mail: iconget@clinic.ub.es

The first 300 words of the full text of this article appear below.

	INTRODUCTION

 
In 2001, Wilkin (1) postulated that type 1 and type 2 diabetes are mostly the same disorder, only distinguished by the rate of ß-cell loss with three different accelerators participating in the process (2,3).

Since 2002, many articles have supported the "accelerator hypothesis," showing that BMI and changes in weight are inversely related to age at diagnosis of type 1 diabetes (4–6). Recently, Knerr et al. (7), in a large cohort of children with type 1 diabetes, concluded that a higher BMI was associated with a younger age at diagnosis of type 1 diabetes and that an increased weight gain could be considered a risk factor for early manifestation of the disease. Dabelea et al. (8) concluded that increasing BMI is associated with younger age at diagnosis only in subjects with a reduced ß-cell function and hypothesized that obesity is accelerating the onset of type 1 diabetes at a higher stage in the natural history of the disease, after substantial autoimmune destruction of the ß-cell has occurred. However, as expected, other studies did not agree with the postulate (9).

Until now, the data testing the accelerator hypothesis comes almost exclusively from Anglo-Saxon and central European populations. The aim of our study was to investigate the relationship between BMI and the age at onset of type 1 diabetes in a large cohort of Mediterranean subjects in whom diabetes became manifest between 1990 and 2004.

	RESEARCH DESIGN AND METHODS—

 
We analyzed data on 3,203 subjects (1,836 male, 2–24 years of age at diagnosis) with newly diagnosed type 1 diabetes included in the Catalan Registry database for new cases of type 1 diabetes between 1990 and 2004 (10). Data on BMI corresponded to information obtained during the 1st week . . . [Full Text of this Article]

	RESULTS—

 

	CONCLUSIONS—

 

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