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Diabetes Care 30:e50 2007
DOI: 10.2337/dc07-0271
© 2007 by the American Diabetes Association
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Online Letters: Comments and Responses

Cortisol Secretion in Patients With Type 2 Diabetes: Relationship With Chronic Complications

Response to Castillo-Quan and Pérez-Osorio

Iacopo Chiodini, MD1, Guido Adda, MD2, Paolo Beck-Peccoz1, Emanuela Orsi, MD1, Bruno Ambrosi3 and Maura Arosio1,2

1 Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy
2 Department of Endocrinology, San Giuseppe-Milanocuore Hospital, Fatebenefratelli Research Association, Milan, Italy
3 Unit of Endocrinology, Department of Medical and Surgical Sciences, University of Milan, IRCCS Policlinico San Donato Institute, San Donato Milanese, Milan, Italy

Address correspondence to Iacopo Chiodini, MD, Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Policlinico, Mangiagalli e Regina Elena, IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy. E-mail: iacopo.chiodini@email.it

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Several papers focused on the possible link between cortisol secretion and physiological and pathological cerebral aging (1,2). The neurological (mainly limbic-hippocampal) degenerative modification during aging has been suggested to be responsible for a hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, and an age-related decrease of HPA sensitivity to cortisol feedback has been reported (2).

In our study . . . [Full Text of this Article]


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Copyright © 2007 by the American Diabetes Association.