Diabetes Care
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Diabetes Care 30:e103 2007
DOI: 10.2337/dc07-1121
© 2007 by the American Diabetes Association
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Online Letters: Comments and Responses

Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A Systematic Review of Randomized Controlled Trials

Response to Kleefstra, Houweling, and Bilo

Ethan M. Balk, MD, MPH1, Alice H. Lichtenstein, DSC2 and Anastassios G. Pittas, MD, MSC3

1 Evidence-Based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts
2 Cardiovascular Nutrition Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
3 Division of Endocrinology, Diabetes, and Metabolism, Tufts–New England Medical Center, Boston, Massachusetts

Address correspondence to Ethan Balk, MD, Tufts-New England Medical Center, Box 63, 750 Washington St., Boston, MA 02111. E-mail: ebalk@tufts-nemc.org

The first 20% of the full text of this article appears below.

We thank Kleefstra et al. for their comments (1) on our review (2), and we appreciate the opportunity to respond. We agree that the available trials on chromium supplementation are of poor quality and have heterogeneous results. Our approach toward systematic review is to not exclude studies based on what are inevitably subjective decisions about quality, applicability, or heterogeneity.

A subanalysis of the chromium picolinate trials excluding Anderson et al. (. . . [Full Text of this Article]


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Copyright © 2007 by the American Diabetes Association.